Research progress in the brain area responsible for depression

Abstract

Depression is one of the main types of affective disorders, which is extremely harmful to the physical and mental health of patients. The typical clinical symptoms of depression include decreased volitional activity, retardation of thinking, low spirits, and cognitive impairment. The pathogenesis of depression is very complex, including multiple factors such as biological, psychological and environmental factors. Researchers at home and abroad have carried out research on depression in many fields. In neuroscience, it has been concluded that the dysfunction of the frontal lobe, hippocampus, temporal lobe, striatum, amygdala and other brain of patients with depression can contribute to depression. Besides, the abnormal connections between these brain regions may also result in depression. Herein, we mainly introduced the current research of the above-mentioned responsible brain regions and related neural circuits for depression, and further summarized the current knowledge about the diagnosis and treatment of depression. Finally, we briefly discussed the feasibility of using rodents as animal models to explore depression.