Development of cell-based vaccines in cancer treatment

Abstract

Cancer, as a serious global disease, becomes a severe threat to human life. Due to the problems of environmental pollution and life habits, many people die each year from various kinds of cancer, which also includes many young and middle-aged people. Nowadays, cancer has become one of the most concerned public health problems in the world, and the efforts and attempts to actively explore new treatments for cancer have never stopped. The creation of therapeutic cancer vaccines has solid biological and preclinical rationales, however, it has been difficult to translate this treatment approach into the clinical therapies. Immunotherapy has gained widespread attention as an emerging tool for cancer treatment. Among them, cell-based vaccines have achieved ideal outcomes in multiple tumor killings. This review introduces vaccines based on induced pluripotent stem cells (iPSC) and dendritic cells (DC), summarizes the related research progress of cell vaccines in cancer treatment and discusses the limitations of cell-based vaccines.