Research progress on the regulation mechanism of the mitotic spindle localization in budding yeast cells

Abstract

Eukaryotic cells distribute genetic material equally to two daughter cells through mitosis to maintain the stability of genetic traits between parents and offspring. The key to the precise distribution of genetic material is spindle localization. Many studies have shown that spindle localization is a very complex life process regulated by many related proteins such as tubulin and dynein. It is not only essential for normal cell activities such as cell division, differentiation, and embryonic development but also related to the occurrence of diseases such as cancer. Over the years, although the regulatory mechanism of spindle localization in different organisms has been reported successively, the research on its regulatory mechanism in budding yeast is more in-depth. Based on the research status of mitotic spindle regulation mechanism of budding yeast cells at home and abroad, this paper summarizes the research progress of spindle localization regulation mechanism and related protein function in budding yeast in recent years.