Congenital insensitivity to pain: the controversy and possible pathophysiology model in progress

Abstract

Congenital insensitivity to pain (CIP) is a disorder that emphasizes the critical role of nociception in protecting against tissue damage and is characterized by repeated injuries, burns, and poor wound healing. CIP is a developmental defect caused by pathogenic genetic variants in multiple genes. Current treatment modalities for patients with CIP are primarily symptomatic, but the first targeted therapies are being tested. Interestingly, this area of research offers new ideas for slow-moving pain, one of the great challenges still unresolved by the medical community.