Pyroptosis in Neurodegenerative disease

Abstract

Neurodegenerative diseases, typically, manifest in the elderly. It is becoming a new epidemic disease over the centuries and causes severe symptom as well as high public cost. Thus, finding the cure of neurodegenerative disease is in urgent need. There has been a lot of interest lately in the neuroinflammation-mediated neuronal death pathway. Aberrant activation of programmed cell death is observed in neurodegenerative disease, leading in undesired loss of neuronal cells and function. Among these, research currently on the pyroptosis, which serves a key function in regulating homeostasis and eliminating unwanted cells, has drawn much attention. Comparing pyroptosis within apoptosis, the unique features of pyroptosis made it possible to be cure of the neurodegenerative disease. Due to its mechanism, it can function differently in different neurodegenerative disease. This review focuses on the characteristics and molecular mechanism of pyrpptosis, in addition, its role in neurodegenerative disease has also been discussed.