Abstract
As the COVID-19 pandemic progresses, more and more strategies to combat this pandemic have been proposed, and the mRNA vaccine against COVID-19 has been considered as one of the most potential therapies to terminate the pandemic. However, a few problems of it have been discovered during the whole investigation, such as instability, poor efficacy. Meanwhile, some researchers illustrated that improving the dose of mRNA vaccine to get better efficacy may induce worse adverse reactions due to the delivery of vaccine was ‘lipid nanoparticles (LNPs)’. High level of LNPs would induce cell death by their toxicity, Therefore, some new modifications of mRNA should be paid attention and applied to produce the new mRNA vaccine. It is possible to promote the development of mRNA vaccine for better stability, efficacy, and lower price. This review introduces current modifications of mRNA vaccines for improved stability and discusses some novel ideas.
Publisher
Darcy & Roy Press Co. Ltd.
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