The relationship between gut microbiota and schizophrenia: Recent research and treatment application

Abstract

Schizophrenia (SZC) is a common, chronic, and severe mental illness. Recent years have witnessed increased study into the link between gut microbiome and psychotic disorders, particularly schizophrenia. Focusing on inflammatory, tryptophan compounds, and BDNF concentrations, we examine the data that currently exists linking intestinal microbiota to schizophrenia and explain how the presumptive dysregulation could fit into accepted theories of the disease's pathophysiology. We looked at recent research and assessed the therapeutic possibility of modifying the intestinal microbiota with prebiotics as adjuvant therapy for schizophrenia. Overall, although the available information on microbiome changes in schizophrenia is extremely erratic and inadequate to draw any firm conclusions. There were successful attempts that decreased the risk of SCZ by interfering with the intestinal microbiota. The gut microbiota is a possible approach to the treatment of schizophrenia.