Research progress on circadian rhythm-related Alzheimer's disease and Cancer

Abstract

Endogenous oscillators include circadian oscillators, which control 24-hour physiological and behavioral processes. Nowadays, 7–16% of people with circadian sleep disorders are young adults or adolescents. On the other hand, there are in excess of six million Alzheimer's patients in the United States. By 2050, it is predicted that the population will nearly triple to 13 million. Numerous facets of mammals biology, such as the coordination of sleep and the immune respond are influenced by the central circadian clock. Unusual sleep-wake cycles and disrupted circadian rhythms are frequent symptoms of Alzheimer's disease (AD), which are typically seen as late effects of the neurodegenerative processes. Additionally, it appears that the amyloid-beta peptide, which is linked to AD, is regulated by the sleep-wake cycle and that altering sleep has a variety of effects on AD pathology in mouse models. Forthemore, cancer's pathophysiology has been clarified by new studies on circadian rhythms and the disease. The connections between irregularities in human circadian clocks and sleep disorders is disscused firstly in this paper. The most recent studies on the possible impact of sleep and circadian rhythms on AD pathogenesis and cancer are introduced. This article reviews the fundamentals of circadian rhythms before moving on to various forms of sleep disorders, cancer, and Alzheimer's disease. This review is significant because it compiles recent research on illnesses connected to the circadian rhythm, including Alzheimer's disease, cancer, and sleep disorders.