The Mechanism of Antihepatocellular Carcinoma and Toxicity Analysis of Huachanin

Abstract

Huachanin is a chemical borrowed from Traditional Chinese Medication practices that is commonly utilized in the treatment of cancer. Its mixture attribute serves in alignment with the typical multiple-target effects of Traditional Chinese Medicine. A majority of researches on Huachanin, however, examine its influences only on single pathways. This review integrates several major mechanisms by which Huachanin acquires hepatoma cancer suppressing functions, namely, the down regulation of Aurora Kinase, induction of apoptosis, and the inhibition of cell autophagy. The review then analyses Huachanin’s cause on nontumor tissue malfunction while suppressing tumor growth, aiming to provide insight into balancing the toxicity and efficacy in Huachanin treatments to maximize its medical potential.