Research on the correlation between intestinal microecology and leukemia

Abstract

Intestinal microecology is the largest and most complex microecological community in the human body and is closely related to human health. About 20% of malignancies are associated with microecological dysbiosis. The gut microbiota of patients with leukemia is significantly different from that of the healthy population. The intestinal flora can be involved in the development and progression of leukemia in many ways through regulation of immune cells, stimulation of inflammation, infection by pathogenic bacteria, action of metabolites, influence of body metabolism and genetic mutations. Chemotherapy, allogeneic hematopoietic stem cell transplantation and chimeric antigen receptor T-cell immunotherapy can cause intestinal flora disorders in leukemia patients, and probiotic therapy can reduce the complications associated with the treatment process. The intestinal microecological stability is beneficial to the treatment of leukemia patients, therefore, the in-depth exploration of methods to maintain the intestinal microecological balance is important for the prolongation of survival of leukemia patients.