Feasible construction of a pH-responsive nanoparticle for smart drug delivery
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Published:2023-11-06
Issue:
Volume:69
Page:463-469
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ISSN:2791-0210
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Container-title:Highlights in Science, Engineering and Technology
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language:
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Short-container-title:HSET
Abstract
Endosomal pH-responsive micellar nanoparticles have been prepared by amphiphilic poly (ethylene glycol)-Schiff base-Adriamycin (PEG-Schiff-DOX，PSD) prodrug, and wrapped DOX drugs in the hydrophobic core of the polymeric nanoparticles. Under normal conditions, these nanoparticles showed good stability over a storage period of 7 days but decomposed rapidly under the weakly acidic conditions. These nanoparticles possessed a high drug loading capacity and good cell compatibility that would be promising for the drug carries in the drug delivery system.
Publisher
Darcy & Roy Press Co. Ltd.
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