Effects of Silkworm Pupae Protein and Active Peptides on Human Immunity

Abstract

The escalating global population and the concomitant scarcity of protein resources have heightened the urgency to explore novel sources of protein. Insects, as a taxonomic class of organisms, are abundantly enriched with superior-quality protein and steered by this premise, they present a prodigious opportunity for human employment and scientific investigation in the realm of biologic resources. The larval stage of the domesticated silkworms, extensively cultivated for their silk, give rise to the universally consumed pupae in East Asia that augment the dietary provisions. This paper provides a comprehensive discussion of the immune-boosting, antibacterial, antitumor, and antioxidant properties of silkworm pupae proteins. Additionally, it explores the possible allergic reactions that may arise from silkworm consumption. Silkworm chrysalis protein, which contains a plethora of bioactive peptides such as AKPGVY and AAEYPA, offers a novel source of antioxidant peptides that have been shown to bolster immune function, enhance the body's capacity to fend off bacteria and viruses, reduce the risk of tumor development, and mitigate adverse effects such as free radical oxidative damage. However, it is important to note that some individuals may be susceptible to allergic reactions to silkworm pupae. Consequently, safety concerns related to the use of silkworm pupae proteins and active peptides should be taken into account.