pH-Sensitive Polymeric Nanoparticles for Effective Delivery of Doxorubicin

Abstract

pH-responsive micelles beam nanoparticles were created using the self-assembly of PEG-Shiff-DOX medication. Under normal circumstances, these nanoparticles have great storage stability for more than a week, however they will degrade fast in a weak acidic environment. We saw a process-dependent drug release behaviour. This could lead to higher intracellular drug concentrations and a more sustained effect. The anti-tumor efficacy of nanoparticles on HeLa cells is superior to that of free DOX, according to the CCK-8 analysis. The potential for creating conversion DOX formulations for the treatment of cancer with these pre-drug-based nano-drugs is enormous.