Circadian rhythm disorder induced type 2 diabetes mellitus: pathogenesis and therapeutics

Abstract

Incidence rate of Type 2 diabetes mellitus (T2DM) is increasing rapidly nowadays. T2DM is related to poor sleep hygiene and shift work, and both circadian rhythm and chronotype may have a significant impact on the risk of T2DM. Many recent studies have shown that the morbidity and treatment of T2DM are significantly related to the pattern and the circadian rhythm (CR). However, there is still a lack of comprehensive knowledge of association between it and T2DM, and there are a lot of gaps in the application and efficacy evaluation of circadian rhythm therapy for T2DM. This review improves the understanding of the pathogenesis of T2DM and further clarifies the influence and significance of CR on glucose metabolism, provides prevention and treatment options for T2DM. And promotes the application and progress of circadian rhythm therapy in the treatment of T2DM based on the effect of CR to T2DM.