Author:
Liu Xueting,Wang Xinmin,Zheng Qianye
Abstract
Ladinin-1 (LAD1) is a protein originally called mammalian epidermal basement membrane collagen anchored silk protein. The molecular weight of the protein is 59 kD. It is a cytoskeleton related protein, responsible for maintaining the the coherence of dermal-epidermal junction, and it helps to connect epithelial cells with underlying mesenchymal cells. Biology of cancer includes aberrant cell differentiation and proliferation, unchecked growth, invasion, and metastasis, among other biological traits. LAD1 affects the migration, metastasis, proliferation and other important physiological processes of cells by regulating its expression, thus affecting the genesis and occurrence of cancer. However, the expression of LAD1 in different cancers has tumor specificity. This article reviews the biological functions of LAD1 in different cancers from breast cancer, colorectal cancer, NSCLC, and cervical cancer. It briefly summarizes the structure of LAD1 and further exploration of cancer-related treatment mechanisms can be provided by understanding its potential molecular mechanism of function in cancer cells LAD1 has potential value in anti-cancer treatment because of its important biological functions.
Publisher
Darcy & Roy Press Co. Ltd.
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