Abstract
The main research focus of this article is the application of Metal-Organic Frameworks (MOFs) in drug delivery applications. The review primarily concentrates on the methods used for loading drugs into MOFs, their response to stimuli, potential applications, and limitations. The article begins with discussing the limitations of traditional drug delivery systems and introduces MOFs as a potential solution to these limitations. The drug loading strategy section describes the three main methods for loading drugs into MOFs, including their respective benefits and drawbacks. The stimulus response release program section explores various stimuli that can trigger drug release from MOFs, including physical, chemical, and biological factors, and provides examples of how MOFs can respond to these stimuli. The section on application and challenges provides an overview of current studies exploring the potential of MOFs in biomedical applications, including cancer therapy, antibacterial therapy, and anti-inflammatory therapy, while also highlighting the key challenges facing MOFs research, such as biocompatibility and toxicity. Finally, the article concludes by offering prospects for future developments in MOFs research. This review article provides a significant resource for drug delivery researchers and practitioners who wish to investigating the possibility of utilizing MOFs as novel drug delivery vehicles.
Publisher
Darcy & Roy Press Co. Ltd.
Reference17 articles.
1. Vargason, A. M.; Anselmo, A. C.; Mitragotri, S. The evolution of commercial drug delivery technologies. Nature Biomedical Engineering 2021, 5 (9), 951 - 967.
2. Drug Delivery Systems National Institute of Biomedical Imaging and Bioengineering, 2022. https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner (accessed 2023 19/March).
3. Adepu, S.; Ramakrishna, S. Controlled Drug Delivery Systems: Current Status and Future Directions. Molecules 2021, 26, 5905.
4. Yaghi, O. M.; Li, G.; Li, H. Selective binding and removal of guests in a microporous metal–organic framework. Nature 1995, 378 (6558), 703 - 706.
5. Horcajada, P.; Serre, C.; Vallet-Regí, M.; Sebban, M.; Taulelle, F.; Férey, G. Metal–Organic Frameworks as Efficient Materials for Drug Delivery. Angewandte Chemie International Edition 2006, 45 (36), 5974 - 5978.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献