GABA System in Anxiety Disorders: A Review of Current and Novel GABAergic Drugs

Abstract

This is an article for defying diverse of drugs in GABA system showing effect in treating anxiety or not. In the passage, the authors discuss the effect and side effect of levetiracetam, gabapentin and pregabalin, tiagabine, and several novel medications which are AZD7325, PF-06372865, BNC-210, SAGE-217. Some of these drugs were certified and has been put into use for decades, while others may be lack of solid test or further experiment for treating anxiety disorders. The main aim of review is evaluating the recent evidence to find out the included GABAergic drugs’ potential that is most likely to be beneficial for future therapy of treating anxiety disorders, listing the effect and side effect according to the research, and making comparison to other types of anti-anxieties. In the result, BNC-210 and SAGE-217, as the novel GABAergic drug, are more effective than others, also with less and mild side effects. All the evidence are collected from the papers that written by authorities.