Clinical Analysis of 2 Cases of Late-onset Myasthenia Gravis

Abstract

Objective: Improve the recognition ability of late-onset myasthenia gravis, reduce misdiagnosis and improve prognosis. Methods: The data of 2 patients with late-onset myasthenia gravis were collected, including basic information, clinical features, auxiliary examinations, treatment and effects. Results:: Both male patients were elderly. The clinical manifestations were bulbar palsy with diplopia or limb weakness. Symptoms were mild in the morning and severe in the evening, and the neostigmine test was positive. According to the criteria, myasthenia gravis was diagnosed, and pyridostigmine treatment was effective. The severity of the condition was different. Tests for myasthenia gravis antibodies, thyroid function, autoimmune antibodies, and tumor markers were also different. Follow-up of treatment effect was required for prognosis. Conclusion: Late-onset myasthenia gravis is easily misdiagnosed. Neurological examination can help to detect skeletal muscle involvement, and medical history can help to detect clinical features. The auxiliary examinations of myasthenia gravis have clinical significance for the diagnosis, treatment and prognosis.