Research Progress on the Relationship between Gastric Microorganisms and the Occurrence and Development of Gastric Cancer

Abstract

The changes of composition and function of gastric microflora are closely related to the occurrence and development of gastric cancer (Gastriccancer, GC). Gastric microflora has great potential as a biomarker for diagnosis and risk assessment of gastric cancer. There is a complex flora structure in the stomach. The changes of gastric microenvironment caused by Helicobacter pylori (H. pylori HP) may change the flora structure and mainly participate in the early process of gastric carcinogenesis. Gastric microflora other than Helicobacter pylori may play a role in the last steps of gastric carcinogenesis. Exploring the mechanism of gastric microorganisms in the occurrence and development of gastric cancer is helpful to provide a basis for early diagnosis and treatment of gastric cancer. This article mainly reviews the role of Helicobacter pylori and other microorganisms in the occurrence and development of gastric cancer.