Preliminary assessment of 225Ac excretion in patients undergoing radionuclide therapy with 225Ac-DOTA-TATE-Reference-Cited by-同舟云学术

Preliminary assessment of 225Ac excretion in patients undergoing radionuclide therapy with 225Ac-DOTA-TATE

Published:2023-10-02 Issue:3 Volume:16 Page:46-55
ISSN:2409-9082
Container-title:Radiatsionnaya Gygiena = Radiation Hygiene
language:
Short-container-title:Radiac. gig. (2008)

Author:

Chipiga L. A.¹^ORCID,Vodovatov A. V.²^ORCID,Mosunov A. A.³,Saprykin K. A.⁴^ORCID,Gromov A. V.⁴^ORCID,Vasiliev S. K.⁵^ORCID,Petryakova A. V.⁶^ORCID,Vazhenina D. A.⁷^ORCID,Odintsova M. V.⁷^ORCID,Nomokonova V. B.⁷^ORCID,Stanzhevsky A. A.⁷^ORCID,Maystrenko D. N.⁷^ORCID

Affiliation:

1. Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being; A. Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian Federation; Almazov National Medical Research Centre of the Ministry of Health of the Russian Federation

2. Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being; Saint-Petersburg State Pediatric Medical University

3. Peter the Great St. Petersburg Polytechnic University

4. Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being

5. 1Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being; Leading Researcher Radium Institute named after V.G. Khlopin JOINT-STOCK COMPANY

6. Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being; The City Hospital No 40 of the Kurortny District

7. A. Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian Federation

Abstract

The aim of this study was to evaluate the activity of 225Ac in urine of patients undergoing radionuclide therapy with 225Ac-DOTA-TATE. Activity concentration was determined in the urine samples collected within 72 hours after injection of 225Ac-DOTA-TATE, using the ORTEC semiconductor gamma spectrometer, model TSP-DX-100T-PAC-PKG-1. Calculation of excreted activities was additionally performed based on scintig- raphy scans of patients receiving 225Ac-DOTA-TATE. Scans were conducted 5 times for each patient: immedi- ately after injection, at 4 hours, and on the 1st, 2nd, and 3rd days after injection of the radiopharmaceutical. Absolute activity values and fractions of the injected activity were calculated based on the specific activity values. The results of the calculated activity concentration values demonstrate that maximum excretion was observed within the four hours after 225Ac-DOTA-TATE injection. Significant differences between the two methods of determining 225Ac activity were observed only on the third day after radiopharmaceutical injection, which allows for the simplification of future experimental work by using indirect radioactivity measurement methods for activity calculations. There were no significant differences between patient groups with different number of 225Ac-DOTA-TATE injection, which allows for the exclusion of this parameter in the evaluation of experimental results. The results of this study represent the first published experimental data on the determi- nation of actinium excretion in patients.

Publisher

SPRI of Radiation Hygiene Prof. PV Ramzaev

Subject

Radiology, Nuclear Medicine and imaging

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