Expression and protein localisation of IGF2in the marsupial placenta

Author:

Ager Eleanor I,Pask Andrew J,Shaw Geoff,Renfree Marilyn B

Abstract

Abstract Background In eutherian mammals, genomic imprinting is critical for normal placentation and embryo survival. Insulin-like growth factor 2 (IGF2) is imprinted in the placenta of both eutherians and marsupials, but its function, or that of any imprinted gene, has not been investigated in any marsupial. This study examines the role of IGF2 in the yolk sac placenta of the tammar wallaby, Macropus eugenii. Results IGF2 mRNA and protein were produced in the marsupial placenta. Both IGF2 receptors were present in the placenta, and presumably mediate IGF2 mitogenic actions. IGF2 mRNA levels were highest in the vascular region of the yolk sac placenta. IGF2 increased vascular endothelial growth factor expression in placental explant cultures, suggesting that IGF2 promotes vascularisation of the yolk sac. Conclusion This is the first demonstration of a physiological role for any imprinted gene in marsupial placentation. The conserved imprinting of IGF2 in this marsupial and in all eutherian species so far investigated, but not in monotremes, suggests that imprinting of this gene may have originated in the placenta of the therian ancestor.

Publisher

Springer Science and Business Media LLC

Subject

Developmental Biology

Cited by 21 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Further understanding of paternal uniparental disomy in Beckwith-Wiedemann syndrome;Expert Review of Endocrinology & Metabolism;2022-11-02

2. Placentation in Marsupials;Advances in Anatomy, Embryology and Cell Biology;2021

3. Protein- und Peptid-Hormone von Vertebraten;Hormone und Hormonsystem - Lehrbuch der Endokrinologie;2020-11-18

4. The role of mammalian foetal membranes in early embryogenesis: Lessons from marsupials;Journal of Morphology;2020-05-06

5. The origins of genomic imprinting in mammals;Reproduction, Fertility and Development;2019

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