Author:
Li Gaizhi,Ma Ke,Rossbach Kathryn,Niu Ying,Li Qiqi,Liu Zhifen,Zhang Kerang
Abstract
Abstract
Background
While depression is increasing worldwide, some patients are diagnosed as having Major Depressive Disorder (MDD), but others are diagnosed with minor depression, however, the potential neuro mechanism is unknown.
Methods
Sixty-two patients with minor depression, 44 adolescents with MDD and 54 healthy adolescents participated in this study. Functional near-infrared spectroscopy (fNIRS), both HAMD and HAMA data were collected from all of the participants.
Results
The result indicates the pervasively decreased activation of BA, 11, 21, 45 and 46 were observed in the MDD group and reduced activation of BA 45 was observed in the minor depression group. However, cortical activation was not observed between the minor depression or MDD groups. Cortical activation was also not correlated with the depressive/anxious score in the minor and MDD groups separately.
Conclusions
Cortical activation was pervasively decreased in the MDD group and slightly reduced in the minor depression group, which may be a potential neural mechanism. As reduced cortical activation in minor depression, interventions in the early stages of minor depression may help slow or even modify the development of the illness.
Funder
National Natural Science Foundation of China Youth Project
National Natural Science Foundation of China
Four “batches” innovation project of invigorating medical through science and technology of Shanxi Province
Publisher
Springer Science and Business Media LLC
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