Alternation in functional connectivity within default mode network after psychodynamic psychotherapy in borderline personality disorder

Author:

Amiri Saba,Mirfazeli Fatemeh Sadat,Grafman Jordan,Mohammadsadeghi Homa,Eftekhar Mehrdad,Karimzad Nazila,Mohebbi Maryam,Nohesara Shabnam

Abstract

Abstract Background Borderline personality disorder (BPD) is characterized by impairments in emotion regulation, impulse control, and interpersonal and social functioning along with a deficit in emotional awareness and empathy. In this study, we investigated whether functional connectivity (FC) within the default mode network (DMN) is affected by 1-year psychodynamic psychotherapy in patients with BPD. Methods Nine BPD patients filled out the demography, Interpersonal Reactive Index (IRI), Toronto Alexithymia Scale 20 (TAS 20), the Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST), and the Borderline Evaluation Severity over Time (BEST) questionnaire. The BPD group (9F) and the control group (9F) had a mean ± SD age of 28.2 ± 5.3 years and 30.4 ± 6.1 years, respectively. BPD subjects underwent longitudinal resting-state fMRI before psychodynamic psychotherapy and then every 4 months for a year after initiating psychotherapy. FC in DMN was characterized by calculating the nodal degree, a measure of centrality in the graph theory. Results The results indicated that patients with BPD present with aberrant DMN connectivity compared to healthy controls. Over a year of psychotherapy, the patients with BPD showed both FC changes (decreasing nodal degree in the dorsal anterior cingulate cortex and increasing in other cingulate cortex regions) and behavioral improvement in their symptoms and substance use. There was also a significant positive association between the decreased nodal degree in regions of the dorsal cingulate cortex and a decrease in the score of the TAS-20 indicating difficulty in identifying feelings after psychotherapy. Conclusion In BPD, there is altered FC within the DMN and disruption in self-processing and emotion regulation. Psychotherapy may modify the DMN connectivity and that modification is associated with positive changes in BPD emotional symptoms.

Funder

Iran University of Medical Sciences

Publisher

Springer Science and Business Media LLC

Subject

Psychiatry and Mental health

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Contemporary neuroscientific concepts and psychotherapy: possibilities for integration;Журнал высшей нервной деятельности им. И.П. Павлова;2024-07-10

2. Current Neuroscientific Concepts and Psychotherapy: Possibilities for Integration;Neuroscience and Behavioral Physiology;2024-06

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