Author:
Chen Xiaomin,Zhou Xiangxiang,Wang Xin
Abstract
AbstractYT521-B homology domain family member 2 (YTHDF2) is an N6-methyladenosine (m6A)-binding protein that was originally found to regulate the stability of mRNA. Growing evidence has shown that YTHDF2 can participate in multifarious bioprocesses, including embryonic development, immune response, and tumor progression. Furthermore, YTHDF2 is closely associated with the proliferation, apoptosis, invasion, and migration of tumor cells, suggesting its significant role in cancers. YTHDF2 primarily relies on m6A modification to modulate signaling pathways in cancer cells. However, the expression and function of YTHDF2 in human malignancies remain controversial. Meanwhile, the underlying molecular mechanisms of YTHDF2 have not been elucidated. In this review, we principally summarized the biological functions and molecular mechanisms of YTHDF2 in tumors and discussed its prognostic and therapeutic values.
Funder
National Natural Science Foundation of China
Key Research and Development Program of Shandong Province
Development Project of Youth Innovation Teams in Colleges and Universities of Shandong Province
China Postdoctoral Science Foundation
Technology Development Projects of Shandong Province
Translational Research Grant of NCRCH
Shandong Provincial Natural Science Foundation
Technology Development Project of Jinan City
Taishan Scholars Program of Shandong Province; Shandong Provincial Engineering Research Center of Lymphoma; Academic Promotion Programme of Shandong First Medical University
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Hematology
Cited by
24 articles.
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