Metabolic cross-talk within the bone marrow milieu: focus on multiple myeloma

Author:

Oudaert Inge,Van der Vreken Arne,Maes Anke,De Bruyne Elke,De Veirman Kim,Vanderkerken Karin,Menu Eline

Abstract

AbstractCancer cells are well-known for their capacity to adapt their metabolism to their increasing energy demands which is necessary for tumor progression. This is no different for Multiple Myeloma (MM), a hematological cancer which develops in the bone marrow (BM), whereby the malignant plasma cells accumulate and impair normal BM functions. It has become clear that the hypoxic BM environment contributes to metabolic rewiring of the MM cells, including changes in metabolite levels, increased/decreased activity of metabolic enzymes and metabolic shifts. These adaptations will lead to a pro-tumoral environment stimulating MM growth and drug resistance In this review, we discuss the identified metabolic changes in MM and the BM microenvironment and summarize how these identified changes have been targeted (by inhibitors, genetic approaches or deprivation studies) in order to block MM progression and survival.

Funder

Fonds Wetenschappelijk Onderzoek

Kom op tegen Kanker

Vrije Universiteit Brussel, Belgium

International Myeloma Foundation

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,Hematology

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