Abstract
Abstract
Background
The successful application of Fish plasma model (FPM) will greatly simplify the risk assessment of drugs. At present, the FPM has been applied to the risk assessment of several human drugs with high hydrophobicity. However, its applicability to a wide variety of compounds needs to be tested. Field work about distribution characteristics of endocrine disrupting compounds (EDCs) in water and in fish plasma plays a key role in promoting the successful application of FPM. However, there are few reports on the distribution of EDCs in fish, especially in wild fish plasma.
Results
The distribution of 31 EDCs, including seven estrogens, eight androgens, six progesterones, five glucocorticoids, and five industrial compounds, in water and plasma of five categories of wild fishes in Taihu Lake was studied and the typical FPM was tested by the field data. The detected concentration of most compounds is relatively low (< 10 ng/L), and the industrial compounds are the predominant pollutants with the highest concentration up to 291.7 ng/L (Bisphenol A) in water. In general, glucocorticoids were detected at the highest concentrations in plasma of all kinds of fishes, followed by industrial compounds and estrogens. Except for glucocorticoids (up to 43.61 for Cortisone), the average concentrations of the other four categories of EDCs in fish plasma were generally low (< 10 μg/L). The available measured bioaccumulation factors (BAFs) of 20 kinds of EDCs were in the range of 0 to 5626. The bioaccumulation of EDCs in fish plasma is not only hydrophobicity-dependent, but is also both fish species-specific and compound-dependent. The classical FPM was tested and the results indicated that the good coincides of measured log BAFs and the theoretical log BCFs were only observed for limited EDCs (7 out of 20). The present available FPM generally underestimated the Log BAFs of most hydrophilic EDCs (log Kow < 3.87, 11 out of 20) whereas overestimated the Log BAFs of several high hydrophobic EDCs (Log Kow > 3.87) in fish plasma.
Conclusion
Although the present FPM is barely satisfactory, it is still promising for predicting the accumulation of EDCs in fish plasma and for further environmental risk assessment.
Funder
National Natural Science Foundation of China
Major Science and Technology Program for Water Pollution Control and Treatment
Publisher
Springer Science and Business Media LLC
Reference56 articles.
1. Wick A, Fink G, Joss A, Siegrist H, Ternes TA (2009) Fate of beta blockers and psycho-active drugs in conventional wastewater treatment. Water Res 43(4):1074. https://doi.org/10.1016/j.watres.2008.11.031
2. Giebner S, Ostermann S, Straskraba S, Oetken M, Wagner M (2016) Effectivity of advanced wastewater treatment: reduction of in vitro endocrine activity and mutagenicity but not of in vivo reproductive toxicity. Environ Sci Pollut Res Int 25(5):1–12
3. Stackelberg PE, Gibs J, Furlong ET, Meyer MT, Zaugg SD, Lippincott RL (2007) Efficiency of conventional drinking-water-treatment processes in removal of pharmaceuticals and other organic compounds. Sci Total Environ 377(2–3):255–272. https://doi.org/10.1016/j.scitotenv.2007.01.095
4. Liu S, Ying GG, Zhao JL, Chen F, Yang B, Zhou LJ, Lai HJ (2011) Trace analysis of 28 steroids in surface water, wastewater and sludge samples by rapid resolution liquid chromatography–electrospray ionization tandem mass spectrometry. J Chromatogr A 1218(10):1367–1378. https://doi.org/10.1016/j.chroma.2011.01.014
5. Wang Y, Wang Q, Hu L, Lu G, Li Y (2015) Occurrence of estrogens in water, sediment and biota and their ecological risk in Northern Taihu Lake in China. Environ Geochem Health 37(1):147–156. https://doi.org/10.1007/s10653-014-9637-0
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