Author:
Nkeck Jan René,Ida Chemgne Marie,Koe Valerie Ndobo,Ndam Antonin Wilson Ndjitoyap,Jessica Yondo Ndedi Claudine,Manuella Eko Ondoa,Charelle Boukeu Yonta,Corine Zouague Zalbi,Andrée Ntyam Abena,Amazia Falmata,Nkeck Jériel Pascal,Samba Esther Astrid Mbono,Moor Vicky Jocelyne Ama
Abstract
Abstract
Objective
The usefulness of gamma glutamyl transferase (GGT) as biomarker of cardiovascular risk (CVR) remains unexplored in sub-Saharan Africans. To evaluate their relevance on CVR assessment in non-diabetic hypertensive Cameroonians. This was a prospective cross-sectional study on non-diabetic hypertensive adults aged 57.7 ± 10 years (62% female), without evidence of acute or chronic liver disease, in which we assessed GGT levels and correlates it with validated CVR biomarkers, CVR scores (WHO risk score, Framingham 2008, ASCVD 2013, EuroSCORE 2003, and Reynolds score), and plasma atherogenic index (PAI).
Results
We found a positive but weak association between GGT and PAI on linear regression [0.004 (0.001; 0.007); p = 0.021], which was dependent of triglycerides levels (r = 0.17; p = 0.03). We did not find a significant association between GGT levels and the results of the CVR scores studied; Although being related to atherogenic risk, as reported in literature in non-sub-Saharan Africans, GGTs would be of little value for CVR assessment in our population.
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
2 articles.
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