Real world data from a multi-centre study on the effects of cilostazol on pain symptoms and walking distance in patients with peripheral arterial disease
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Published:2022-12-20
Issue:1
Volume:15
Page:
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ISSN:1756-0500
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Container-title:BMC Research Notes
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language:en
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Short-container-title:BMC Res Notes
Author:
Katsiki Niki, Tentolouris Nikolaos, Marakomichelakis Georgios, Richter Dimitrios, Giannoukas Athanasios, Koufaki Panagiota, Papanas NikolaosORCID, Alexopoulos Ilias, Anastasiadis Filippos, Andreadis Evangelos, Andreopoulos Georgios, Apostolidis Dimitris, Christodoulou Ioannis, Christopoulos Ioannis, Dalaberis Eleftherios, Daliani Hermioni, Dimitriou Giorgos, Dimitsikoglou Iordanis, Dimoulis Nikolaos, Doulgerakis Dimitrios, Douloumpakas Ioannis, Drakopoulou Efrosyni, Felekis Theodoros, Feloukas Theodoros, Florou Sofia, Fragakis Dimitrios, Fregidis Theodoros, Gakis Panagiotis, Galanakis Christos, Giakoumis Antonios, Giannes Nikolaos, Galapis Alexandros, Gouveris Ioannis, Groutsis Theodoros, Grapsas Vasileios, Grigoropoulos Panagiotis, Iordanidis Triantafyllos, Kazakos Kyriakos, Kazantzi Maria, Kapernopoulos Haralabos, Kapetanios Konstantinos, Karagianni Eleni, Karakostas Fotis, Karapiperis Dimitris, Karotsis Antonios, Karsanidis Abraam, Kasfikis Fotios, Kourouklis Spyridon, Kourtis Tsampikos, Kourtidou Paraskevi, Koutsias Stylianos, Kotsogiannis Stavros, Lampousakis Ioannis, Latsios Panagiotis, Liouri Irine, Makrygiannis Panagiotis, Matsouki Welcome, Bakalakou Konstantina, Bakiris Pavlos, Balogianni Maria, Benis Apostolos, Beri Vasiliki, Beroukas Antonios, Moysidis Konstantinos, Nanos Efstathios, Nikolaou Achilleas, Dubovina Marina, Oikonomidis Nikolaos, Pangalos Emmanouil, Panagoulias Georgios, Papadopoulos Savvas, Paraskevas Georgios, Peroulis Michael, Petoumenos Vasilis, Petrogiannis Spyridon, Pournaras Georgios, Pourou Helena, Prionidis Markos, Rigas Antonios, Rigas Spyridon, Rigopoulos Dimitrios, Sakellariou Dimitrios, Sarafianos Periklis, Svolis Konstantinos, Seferou Maria, Sklirou Vasiliki, Spais Georgios, Stathopoulos Christos, Stavridou Victoria, Stavrou Ioannis, Sfiniadakis Ioannis, Tatola Vagia, Topalidis Isaak, Trikkalinou Aikaterini, Tsagarakis Dimitrios, Tsarouchas Panagiotis, Valkaniotis Georgios, Varella Maria, Vasilakakou Stavroula, Vlachopoulou Maria, Vouzas Antonios, Zafeiriou Ioannis, Zafeiris Ioannis, Zacharopoulou Ourania, Zinelis Dimosthenis,
Abstract
Abstract
Objective
to assess the effects of cilostazol on pain-free walking distance in PAD patients with IC at 3 and 6 months in a real world, prospective, observational study. We included 1015 PAD patients presenting with IC (71.3% men, 93.5% white, mean age 69.2 ± 8.7 years). Patients were followed up for 6 months by their physicians.
Results
Cilostazol significantly increased pain-free walking distance by a median of 285 and 387 m at 3 and 6 months, respectively (p < 0.01 for all comparisons). This effect was significant for patients 50–74 years (but not for those aged ≥ 75 years) and independent of smoking status, changes in physical activity, comorbidities and concomitant medication for PAD (i.e., acetylsalicylic acid and clopidogrel). Furthermore, significant reductions were observed in systolic (from 139 ± 16 to 133 ± 14 mmHg; p < 0.001) and diastolic blood pressure (from 84 ± 9 mmHg to 80 ± 10 mmHg; p < 0.001). Smoking cessation and increased physical activity were reported by the majority of participants. In conclusion, cilostazol was shown to safely decrease pain symptoms and improve pain-free walking in PAD patients with IC in a real world setting. Benefits also occurred in terms of BP and lifestyle changes.
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
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