Abstract
Abstract
Objectives
This study examines the rationale, if any, behind combining the extracts from the fruits of Alchornea cordifolia and Pterocarpus santalinoides and aerial parts of Cassytha filiformis in the traditional treatment of diarrhoegenic bacterial infections.
Results
Four diarrhoegenic bacterial isolates: Salmonella typhi, Shigellae dysenteriae, Escherichia coli and Staphylococcus aureus were used and their antibiotic susceptibility screening showed that they were multi-antibiotic resistant. The extracts exhibited activity against all the test isolates with minimum inhibitory concentration values ranging from 3.125 to 12.5 mg/mL. From the checkerboard assay, the fractional inhibitory concentration indices showed that C. filiformis has antagonistic and indifference activities in combination with either P. santalinoides or A. cordifolia. This showed that the combination of extracts from the fruits of A. cordifolia and P. santalinoides and aerial parts of C. filiformis is counterproductive and invalidates any claim for positive results in the management of diarrhoegenic bacterial infections.
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference42 articles.
1. Adonu CC, Esimone CO, Attama AA, Ugwueze MC. In vitro evaluation of antibacterial activity of extracts from Cassytha filiformis linn against urogenital clinical gram-negative bacteria. Int J Pharm Biol Sci. 2013;3(2):99–107.
2. Adonu CC, Enwa FO, Anie CO, Gugu T, Esimone CO, Attama AA. In vitro evaluation of the combined effects of methanol extracts from Cassytha filiformis and Cleistopholis patens against Pseudomonas aeruginosa and Escherichia coli. Int J Adv Res. 2013;1(5):152–8.
3. Ihedioha TE, Okechukwu VN, Ihedioha JI. Effects of aqueous leaf infusion of Pterocarpus santalinoides DC on the serum lipid profile of guinea pigs (Carvia porcellus). J Complement Med Res. 2018;7(2):154–60.
https://doi.org/10.5455/jcmr.20180113015556
.
4. Lifongo LL, Simoben CV, Ntie-Kang F, Babiaka SB, Judson PN. A bioactivity versus ethnobotanical survey of medicinal plants from Nigeria, West Africa. Nat Prod Bioprospect. 2014;4(1):1–19.
https://doi.org/10.1007/s13659-014-0005-7
.
5. Mythili S, Gajalakshmi S, Sathiavelu A, Sridharan TB. Pharmacological activities of cassytha filiformis: a review. Asian J Plant Sci Res. 2011;1(1):77–83.
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