Author:
Moghimi Mansour,Tavakoli Forough,Doosti Masoud,Ahmadi-Vasmehjani Abbas,Akhondi-Meybodi Mohsen
Abstract
Abstract
Objectives
Recent studies using genome-wide association studies (GWAS) have shown the strong association between polymorphisms near the interleukin-28B (IL-28B) gene and spontaneous clearance of hepatitis C virus (HCV). The present study was designed to evaluate the association of interleukin-28 gene polymorphism with interleukin-28 cytokine levels in different viral genotypes among HCV patients in Yazd, Iran.
Result
The most prevalent genotype in chronic cases was genotype 3a, and the lowest one was 2/3a. There were statistically significant differences in genotype frequency between the two studied groups for IL-28B rs12979860C/T. The frequency of CC genotype of IL-28B at rs12979860 SNP was higher in spontaneously cleared patients in comparison with chronic HCV patients. Significant association was found when serum levels of IL28B were compared to various IL-28 genotypes. There was a significant difference between IL-28 polymorphism and HCV genotypes (p = 0.003).
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference35 articles.
1. Hajarizadeh B, Razavi-Shearer D, Merat S, Alavian SM, Malekzadeh R, Razavi H. Liver disease burden of hepatitis C virus infection in Iran and the potential impact of various treatment strategies on the disease burden. Hepat Mon. 2016;16(7):e37234.
2. Rahimi P, Solati R, Shokri M, Vahabpour R, Mahmoudizad F, Aghasadeghi M, et al. Evaluation of full length E1 and E2 glycoproteins of HCV expressed in P. pastoris as a protein-based vaccine candidate. Vacc Res. 2015;2(3):74–80.
3. Mirminachi B, Mohammadi Z, Merat S, Neishabouri A, Sharifi AH, Alavian SH, et al. Update on the prevalence of hepatitis C virus infection among Iranian general population: a systematic review and meta-analysis. Hepat Mon. 2017;17(2):e42291.
4. Sarvari J, Mansouri M, Hashempoor T, Hosseini SY, Moattari A, Pirbonyeh N, et al. Association of genotype and haplotype of IL-28B gene with hepatitis C infection outcome in Iran: spontaneous clearance versus chronic infection. Hepat Mon. 2017;17(5):e45745.
5. Tameshkel FS, Niya MHK, Sohrabi M, Panahi M, Zamani F, Imanzade F, et al. Polymorphism of IL-28B gene (rs12979860) in HCV genotype 1 patients treated by pegylated interferon and ribavirin. Iran J Pathol. 2016;11(3):216.
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