Author:
Okazaki Mitsuyoshi,Katano Kaoru,Sugita Hiroaki,Tokoro Tomokazu,Gabata Ryousuke,Takada Satoshi,Nakanuma Shinichi,Makino Isamu,Yagi Shintaro
Abstract
Abstract
Background
Synovial sarcoma is a malignant tumor that constitutes up to 10% of all soft-tissue sarcomas. The most frequent metastatic sites of synovial sarcoma are the lungs, lymph nodes, and bone, whereas pancreatic metastasis is extremely rare. Here, we report a case of pancreatic metastasis of synovial sarcoma.
Case presentation
Nine years before presentation, a 31-year-old woman underwent extensive resection of the primary tumor after chemotherapy for left upper extremity synovial sarcoma. Six months before presentation, interscapulothoracic amputation was performed for an enlarged mass in the left upper extremity; the patient was treated with pazopanib. Three months before presentation, chest computed tomography showed multiple lung metastases; during subsequent follow-up, abdominal computed tomography revealed a pancreatic metastasis of synovial sarcoma. The doubling time of the pancreatic tumor was 14 days, and it grew rapidly. Furthermore, treatment-resistant pancreatitis symptoms were detected; thus, we performed distal pancreatectomy and administered one course of a 70% dose of trabectedin. However, the patient died of rapid progression of lung metastasis and respiratory failure within 2 months after surgery.
Conclusions
Pancreatectomy may be carefully performed in cases of isolated pancreatic metastasis. However, the presence of other distant extrapancreatic metastases (e.g., uncontrolled lung metastases) may rule out pancreatectomy treatment.
Publisher
Springer Science and Business Media LLC
Subject
Industrial and Manufacturing Engineering,General Business, Management and Accounting,Materials Science (miscellaneous),Business and International Management
Reference21 articles.
1. Takenaka S, Ueda T, Naka N, Araki N, Hashimoto N, Myoui A. Prognostic implication of SYT-SSX fusion type in synovial sarcoma: a multi-institutional retrospective analysis in Japan. Oncol Rep. 2008;19:467–76.
2. Mark DM, Michael SG, Bryan TJ, Ana MC, Julie F, Donald AG. From the archives of the AFIP: imaging of synovial sarcoma with radiologic-pathologic correlation. Radiographics. 2006;26:1543–65.
3. Amit B, Atul BS, Katherine MK, Stephanie AH, Jyothi PJ, Jason LH. Synovial sarcoma: imaging features of common and uncommon primary sites, metastatic patterns, and treatment response. Am J Roentgenol. 2012;199:W208–15.
4. Iyad S, Carlos R, Raya S, Sameer Y, Michela C, Andrea F. Comparing children and adults with synovial sarcoma in the surveillance, epidemiology, and end results program, 1983 to 2005: an analysis of 1268 patients. Cancer. 2009;115:3537–47.
5. Bassi C, Marchegiani G, Dervenis C, Sarr M, Abu Hilal M, Adham M. The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 years after. Surgery. 2017;161:584–91.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献