Author:
Avasarala Jagannadha R,Chittur Sridar V,George Ajish D,Tine John A
Abstract
Abstract
Background
We investigated if global gene expression and transcription networks in B-lymphocytes of siblings with multiple sclerosis (MS) were different from healthy siblings.
Results
Using virus-transformed immortalized B cells and human whole genome bioarrays with validation using RT-qPCR, we found that in siblings with MS, genes for CXCL10, serpin B1 and FUT4 were up regulated whereas CDC5L, TNFRSF19 and HLA-DR were down regulated, among others; transcription analysis showed two intersecting clusters of transcriptional factors - the larger, governed by the upregulated transcription factor 2 (TCF2) and the smaller network regulated by the downregulated CDC5L.
Conclusion
No study has linked TCF2 to MS and to better understand the role of TCF2 in MS, studies in larger cohorts are required.
Publisher
Springer Science and Business Media LLC
Subject
Genetics(clinical),Genetics
Cited by
14 articles.
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