Author:
Badwaik Vivek D,Vangala Lakshmisri M,Pender Dillon S,Willis Chad B,Aguilar Zoraida P,Gonzalez Matthew S,Paripelly Rammohan,Dakshinamurthy Rajalingam
Abstract
Abstract
The antimicrobial properties of dextrose-encapsulated gold nanoparticles (dGNPs) with average diameters of 25, 60, and 120 nm (± 5) and synthesized by green chemistry principles were investigated against both Gram-negative and Gram-positive bacteria. Studies were performed involving the effect of dGNPs on the growth, morphology, and ultrastructural properties of bacteria. dGNPs were found to have significant dose-dependent antibacterial activity which was also proportional to their size. Experiments revealed the dGNPs to be bacteriostatic as well as bactericidal. The dGNPs exhibited their bactericidal action by disrupting the bacterial cell membrane which leads to the leakage of cytoplasmic content. The overall outcome of this study suggests that green-synthesized dGNPs hold promise as a potent antibacterial agent against a wide range of disease-causing bacteria by preventing and controlling possible infections or diseases.
Publisher
Springer Science and Business Media LLC
Subject
Condensed Matter Physics,General Materials Science
Reference48 articles.
1. So AD, Gupta N, Brahmachari SK, Chopra I, Munos B, Nathan C, Outterson K, Paccaud JP, Payne DJ, Peeling RW, Spigelman M, Weigelt J: Towards new business models for R&D for novel antibiotics. Drug Resist Update 2011, 14: 89–94.
2. Salerno F, Cazzaniga M: Therapeutic strategies and emergence of multiresistant bacterial strains. Intern Emerg Med 2010, 5: 45–51. 10.1007/s11739-010-0447-9
3. Zhao Y, Tian Y, Cui Y, Liu W, Ma W, Jiang J: Small molecule-capped gold nanoparticles as potent antibacterial agents that target gram-negative bacteria. J Am Chem Soc 2010, 132: 12349–12356. 10.1021/ja1028843
4. Balland O, Pinto-Alphandary H, Viron A, Puvion E, Andremont A, Couvreur P: Intracellular distribution of ampicillin in murine macrophages infected with Salmonella typhimurium and treated with (3H) ampicillin-loaded nanoparticles. J Antimicrob Chemother 1996, 37: 105–115.
5. Rosemary MJ, MacLaren I, Pradeep T: Investigations of the antibacterial properties of ciprofloxacin@SiO2. Langmuir 2006, 22: 10125–10129. 10.1021/la061411h
Cited by
78 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献