Author:
Hong Myeongjin,Ju Min Jae,Yoon Jeonggyo,Lee Wonyoung,Lee Seula,Jo Eun-kyung,Choi Seo-Youn,Yang Wonho,Choi Yoon-Hyeong
Abstract
Abstract
Background
Humidifier disinfectants (HDs) were commonly used household chemicals to prevent microbial growth in a humidifier water tank in South Korea. A growing body of evidence has indicated that its airborne exposure can induce severe lung injury. However, there has been low awareness of other health outcomes in HD users. This study aimed to evaluate health conditions appealed by claimants for compensation in relation with an increased exposure to HD.
Methods
From survey data of personal HD exposure assessment of claimants for compensation in Korea, we included a total of 4,179 subjects [cases in each dataset were defined by nine reported health conditions, i.e., pneumonia, asthma, cardiovascular disease, respiratory disease, otorhinolaryngologic disease, brain disease (including cerebrovascular disease), dermatological disease, lung cancer, and all cancers]. HD exposures was considered as the following exposure criteria: exposure duration, exposure proximity, exposure direction, chemical type, cumulative exposure time, indoor air concentration, and cumulative exposure level. Logistic regression models were used to evaluate the associations between HD exposure and health conditions.
Results
After adjusting for sociodemographic and health behavioral factors and other chemical exposures (households, environmental, and occupational exposures), an increase in cumulative HD exposure time was significantly associated with risks of all nine diseases (all p-trends < 0.05). An increase in HD exposure duration was associated with asthma, respiratory disease, otorhinolaryngologic disease, dermatological disease, all cancers, and lung cancer (p-trends < 0.05). Indoor HD concentration was associated with only pneumonia (p-trend = 0.015).
Conclusions
Our findings suggest that cumulative exposures to airborne HD might potentially increase the risk of various reported health outcomes.
Publisher
Springer Science and Business Media LLC
Subject
Public Health, Environmental and Occupational Health
Reference31 articles.
1. Korea Center for Disease Control and Prevention. Interim report of epidemiological investigation on lung injury with unknown cause in Korea. Public Health Weekly Report KCDC. Osong, Cheongju, Korea: Korea Center for Disease Control and Prevention. 2011;4:1–2.
2. Yoon J, Kang M, Jung J, Ju MJ, Jeong SH, Yang W, et al. Humidifier disinfectant consumption and humidifier disinfectant-associated lung injury in South Korea: a nationwide population-based study. Int J Environ Res Public Health. 2021;18(11):6136.
3. Park D-U, Ryu S-H, Roh H-S, Lee E, Cho H-J, Yoon J, et al. Association of high-level humidifier disinfectant exposure with lung injury in preschool children. Sci Total Environ. 2018;616:855–62.
4. Hong S-B, Kim HJ, Huh JW, Do K-H, Jang SJ, Song JS, et al. A cluster of lung injury associated with home humidifier use: clinical, radiological and pathological description of a new syndrome. Thorax. 2014;69(8):694–702.
5. Lung Injury Investigation Committee. White paper on the health damage disaster from humidifier disinfectants. Sejong, Korea: Ministry of Health and Welfare; 2014. p. 12–99.