Author:
Qi Xinyu,Liu Maoxing,Xu Kai,Gao Pin,Tan Fei,Yao Zhendan,Zhang Nan,Yang Hong,Zhang Chenghai,Xing Jiadi,Cui Ming,Su Xiangqian
Abstract
Abstract
Background
Postoperative symptomatic anastomotic leakage (AL) is a serious complication after low anterior resection (LAR) for rectal cancer. AL can potentially affect short-term patient outcomes and long-term prognosis. This study aimed to explore the risk factors and long-term survival of symptomatic AL after laparoscopic LAR for rectal cancer.
Methods
From May 2009 to May 2015, 298 consecutive patients who underwent laparoscopic LAR for rectal cancer with or without a defunctioning stoma were included in this study. Univariate and multivariate logistic regression analyses were used to explore independent risk factors for symptomatic AL. Survival analysis was performed using Kaplan–Meier curves, and log-rank tests were used for group comparisons.
Results
Among the 298 patients enrolled in this study, symptomatic AL occurred in eight (2.7%) patients. The univariate analysis showed that age of ≤65 years (P = 0.048), neoadjuvant therapy (P = 0.095), distance from the anal verge (P = 0.078), duration of operation (P = 0.001), and pathological tumor (T) category (P = 0.004) were associated with symptomatic AL. The multivariate analysis demonstrated that prolonged duration of operation (P = 0.010) was an independent risk factor for symptomatic AL after laparoscopic LAR for rectal cancer. No statistically significant differences were observed in the 3-year (P = 0.785) and 5-year (P = 0.979) overall survival rates.
Conclusions
A prolonged duration of operation increased the risk of symptomatic AL after laparoscopic LAR for rectal cancer. An impact of symptomatic AL on a long-term survival was not observed in this study; however, further studies are required.
Trial registration
This study was registered in the Chinese Clinical Trial Registry (ChiCTR2000033413) on May 31, 2020.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Beijing Municipality
Capital’s Funds for Health Improvement and Research
Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support
Beijing Municipal Administration of Hospitals Incubating Program
Beijing Excellent Talent Training Funding
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
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