Author:
Ni Zhizhan,Cao Yuepeng,Liu Liming,Huang Chenshen,Xie Huahao,Zhou Jinzhe,Ge Bujun,Huang Qi
Abstract
Abstract
Background
Self-expanding metal stents (SEMS) served as a bridge to surgery (BTS). However, this method may be associated with worse long-term prognosis and relapse of CRC patients. Therefore, we attempted to clarify this in the angle of circulating tumor cells (CTCs).
Methods
A multicenter study was performed from March 2018 to January 2021. Thirty-two colorectal cancer patients with obstruction were selected, of which 21 patients were performed SEMS as a BTS while 11 patients were performed emergency surgery. Bloods samples were collected in two groups of patients for further detecting CTCs. In the SEMS group, the samples were collected before and after stent insert and after radical surgery performed. In the ES group, the samples were collected before stent insert and after emergency surgery performed.
Results
The number of CTCs did not show statistically significant differences before and after stent placement (34.90 vs 38.33, p=0.90), neither between the SEMS group and ES group in initial CTC levels (34.90 vs 58.09, p=0.394). No significant differences (38.33 vs 58.09, p=0.632) were observed after stent insert in the SMES group and the initial CTC levels in the ES group. Moreover, no major differences (24.17 vs 42.27, p=0.225) were observed after radical operation performed in both groups.
Conclusion
The treatment of SEMS does not cause an increase in the number of CTC after stent insertion. Furthermore, there are may be other factors besides CTC to cause these poorer oncologic outcomes after SEMS placement.
Funder
Zhejiang Province Medical Project
Ningbo Public Welfare Science and Technology Project
Scientific Research Program of Shanghai Science and Technology Commission
Clinical Research and Cultivation Project of Shanghai Tongji Hospital
Publisher
Springer Science and Business Media LLC
Cited by
1 articles.
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