Author:
JamaliMoghadamSiahkali Saeidreza,Zarezade Besharat,Koolaji Sogol,SeyedAlinaghi SeyedAhmad,Zendehdel Abolfazl,Tabarestani Mohammad,Sekhavati Moghadam Ehsan,Abbasian Ladan,Dehghan Manshadi Seyed Ali,Salehi Mohamadreza,Hasannezhad Malihe,Ghaderkhani Sara,Meidani Mohsen,Salahshour Faeze,Jafari Fatemeh,Manafi Navid,Ghiasvand Fereshteh
Abstract
Abstract
Background
Vitamin C is an essential water-soluble nutrient that functions as a key antioxidant and has been proven to be effective for boosting immunity. In this study, we aimed to assess the efficacy of adding high-dose intravenous vitamin C (HDIVC) to the regimens for patients with severe COVID-19 disease.
Methods
An open-label, randomized, and controlled trial was conducted on patients with severe COVID-19 infection. The case and control treatment groups each consisted of 30 patients. The control group received lopinavir/ritonavir and hydroxychloroquine and the case group received HDIVC (6 g daily) added to the same regimen.
Results
There were no statistically significant differences between two groups with respect to age and gender, laboratory results, and underlying diseases. The mean body temperature was significantly lower in the case group on the 3rd day of hospitalization (p = 0.001). Peripheral capillary oxygen saturations (SpO2) measured at the 3rd day of hospitalization was also higher in the case group receiving HDIVC (p = 0.014). The median length of hospitalization in the case group was significantly longer than the control group (8.5 days vs. 6.5 days) (p = 0.028). There was no significant difference in SpO2 levels at discharge time, the length of intensive care unit (ICU) stay, and mortality between the two groups.
Conclusions
We did not find significantly better outcomes in the group who were treated with HDIVC in addition to the main treatment regimen at discharge.
Trial registration irct.ir (IRCT20200411047025N1), April 14, 2020
Funder
Tehran University of Medical Sciences and Health Services
Publisher
Springer Science and Business Media LLC
Cited by
106 articles.
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