Author:
Guan Huifang,Tian Jiaxing,Wang Ying,Niu Ping,Zhang Yuxin,Zhang Yanjiao,Fang Xinyi,Miao Runyu,Yin Ruiyang,Tong Xiaolin
Abstract
AbstractType 2 diabetes mellitus (T2DM) poses a significant global health burden. This is particularly due to its macrovascular complications, such as coronary artery disease, peripheral vascular disease, and cerebrovascular disease, which have emerged as leading contributors to morbidity and mortality. This review comprehensively explores the pathophysiological mechanisms underlying these complications, protective strategies, and both existing and emerging secondary preventive measures. Furthermore, we delve into the applications of experimental models and methodologies in foundational research while also highlighting current research limitations and future directions. Specifically, we focus on the literature published post-2020 concerning the secondary prevention of macrovascular complications in patients with T2DM by conducting a targeted review of studies supported by robust evidence to offer a holistic perspective.
Funder
National Outstanding Youth Science Fund Project of National Natural Science Foundation of China
Capital Health Development Research Special Youth Talent Project
China Academy of Traditional Chinese Medicine Outstanding Youth Technology Talent Training Special Project
Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences
Translational Medicine National Major Scientific and Technological Infrastructure (Shanghai) Open Topic Project
Publisher
Springer Science and Business Media LLC