Current progression in application of extracellular vesicles in central nervous system diseases-Reference-Cited by-同舟云学术

Current progression in application of extracellular vesicles in central nervous system diseases

Published:2024-01-03 Issue:1 Volume:29 Page:
ISSN:2047-783X
Container-title:European Journal of Medical Research
language:en
Short-container-title:Eur J Med Res

Author:

Zhang Xiang-Min,Huang Jie,Ni Xiao-Ying,Zhu Hui-Ru,Huang Zhong-Xin,Ding Shuang,Yang Xin-Yi,Tan Yan-Di,Chen Jian-Fu,Cai Jin-Hua

Abstract

AbstractEarly diagnosis and pharmacological treatment of central nervous system (CNS) diseases has been a long-standing challenge for clinical research due to the presence of the blood–brain barrier. Specific proteins and RNAs in brain-derived extracellular vesicles (EVs) usually reflect the corresponding state of brain disease, and therefore, EVs can be used as diagnostic biomarkers for CNS diseases. In addition, EVs can be engineered and fused to target cells for delivery of cargo, demonstrating the great potential of EVs as a nanocarrier platform. We review the progress of EVs as markers and drug carriers in the diagnosis and treatment of neurological diseases. The main areas include visual imaging, biomarker diagnosis and drug loading therapy for different types of CNS diseases. It is hoped that increased knowledge of EVs will facilitate their clinical translation in CNS diseases.

Publisher

Springer Science and Business Media LLC

Subject

General Medicine

Link

https://link.springer.com/content/pdf/10.1186/s40001-023-01606-5.pdf

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