Abstract
Abstract
Background
July 20th, 2022, marks the 200th anniversary of the “Father of Genetics,” Gregor Mendel’s birth. His experiments with pea plants established the fundamental principles of genetic inheritance.
Main text
In this article, a succinct review of literature is hereby done to answer two key questions: (1) How Mendel’s principles of genetic inheritance helped us understand Mendelian disorders? and (2) How the study of Mendelian disorders can help us understand complex diseases?
Conclusion
This literature review concludes that continued effort to understand the genetic basis of Mendelian disorders will improve our understanding and treatment strategies for complex diseases.
Publisher
Springer Science and Business Media LLC
Reference16 articles.
1. Eisenstein M (2021) Fix the gene, cure the disease. Nat Outlook 596:S2–S4
2. Birchler JA (2015) Mendel, mechanisms, models, marketing, and more. Cell 163:9–11
3. Stern C (1965) Mendel and human genetics. Proc Am Philos Soc 109(4):216–226
4. Zimmer C (2018) She has her Mothers laugh: the powers, perversions, and potential of heredity. Dutton (Penguin Random House LLC), New York
5. Lappalainen T, MacArthur DG (2021) From variant to function in human disease genetics. Science 373:1464–1468