An association study of IL2RA polymorphisms with cerebral palsy in a Chinese population
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Published:2022-10-04
Issue:1
Volume:15
Page:
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ISSN:1755-8794
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Container-title:BMC Medical Genomics
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language:en
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Short-container-title:BMC Med Genomics
Author:
Qiao Yimeng,Wang Yangong,Xu Yiran,Zhang Jin,Su Yu,Cheng Ye,Bi Dan,Song Juan,Xia Lei,Li Ming,Zhang Xiaoli,Zhu Dengna,Wang Ting,Ding Jian,Wang Xiaoyang,Zhu Changlian,Xing Qinghe
Abstract
Abstract
Background
Cerebral palsy (CP), the most common physical disability of childhood, is a nonprogressive movement disorder syndrome. Eighty percent of cases are considered idiopathic without a clear cause. Evidence has shown that cytokine abnormalities are widely thought to contribute to CP.
Methods
An association between 6 SNPs (rs12244380, rs2025345, rs12722561, rs4749926, rs2104286 and rs706778) in IL2RA (interleukin 2 receptor subunit alpha) and CP was investigated using a case–control method based on 782 CP cases and 778 controls. The allele, genotype and haplotype frequencies of SNPs were assessed using the SHEsis program. Subgroup analyses based on complications and clinical subtypes were also conducted.
Results
Globally, no differences in genotype or allele frequencies for any SNPs remained significant after Bonferroni correction between patients and controls, except rs706778, which deviated from Hardy–Weinberg equilibrium and was excluded from further analyses. However, subgroup analysis revealed a significant association of rs2025345 with spastic tetraplegia (P genotype = 0.048 after correction) and rs12722561 with CP accompanied by global developmental delay (P allele = 0.045 after correction), even after Bonferroni correction.
Conclusions
These findings indicated that genetic variations in IL2RA are significantly associated with CP susceptibility in the Chinese Han population, suggesting that IL2RA is likely involved in the pathogenesis of CP. Further investigation with a larger sample size in a multiethnic population is needed to confirm the association.
Funder
Shanghai Municipal Commission of Science and Technology Research Project
the National Natural Science Foundation of China
the National Key Research and Development Program of China
the National Key Research and Development Plan for Stem Cell and Transformation Research
the collaborative innovation center project construction for Shanghai women and children's health
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics
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