The biliary tree musketeers: cholangiocarcinoma – one name for all, but at least three different diseases with distinct targets

Author:

Marins Lidiane VieiraORCID,Moniz Camila Motta Venchiarutti,Freire Cecília Souza,Campos Antonio Hugo José Fróes Marques

Abstract

AbstractCholangiocarcinoma, a malignant neoplasm of the biliary system, poses a significant challenge in clinical practice due to its increasing incidence and diagnostic and therapeutic complexity. This review addresses the epidemiological aspects, risk factors, and classification of this disease. We examine advances in histological diagnosis, highlighting essential criteria for accurate assessment. Additionally, we discuss standard treatment approaches and their efficacy, alongside the latest innovations in therapy, including emerging biomarkers and targeted therapies. By providing a comprehensive overview of these topics, this article aims to enhance understanding and guide the pathological diagnosis and clinical management of this devastating disease.

Publisher

Springer Science and Business Media LLC

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