Author:
Li Yi,Zou Congying,Li Jieying,Wang Wen,Guo Yue,Zhao Lifang,Jiang Chunguo,Zhao Peng,An Xingqin
Abstract
Abstract
Background
Characteristics of airway microbiota might influence asthma status or asthma phenotype. Identifying the airway microbiome can help to investigate its role in the development of asthma phenotypes or small airway function.
Methods
Bacterial microbiota profiles were analyzed in induced sputum from 31 asthma patients and 12 healthy individuals from Beijing, China. Associations between small airway function and airway microbiomes were examined.
Results
Composition of sputum microbiota significantly changed with small airway function in asthma patients. Two microbiome-driven clusters were identified and characterized by small airway function and taxa that had linear relationship with small airway functions were identified.
Conclusions
Our findings confirm that airway microbiota was associated with small airway function in asthma patients.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Beijing Municipality
Publisher
Springer Science and Business Media LLC
Subject
Microbiology (medical),Microbiology
Cited by
5 articles.
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