Author:
Ortega Pilar E. Núñez,Meneses María E.,Delgado-Enciso Iván,Irecta-Nájera César Antonio,Castro-Quezada Itandehui,Solís-Hernández Roberto,Flores-Guillén Elena,García-Miranda Rosario,Valladares-Salgado Adán,Locia-Morales Daniel,Ochoa-Díaz-López Héctor
Abstract
Abstract
Background
Metabolic syndrome (MetS) is a complex cluster of risk factors, considered as a polygenic and multifactorial entity. The objective of this study was to determine the association of rs9939609-FTO polymorphism and MetS components in adult women of Mayan communities of Chiapas.
Methods
In a cross-sectional study, sociodemographic, anthropometric, clinical, and biochemical data were obtained from 291 adult women from three regions of Chiapas, Mexico. The prevalence of MetS and the allele and genotype frequencies of the rs9939609-FTO were estimated. Multivariate logistic regression models were used to assess the association of the single nucleotide polymorphism (SNP) with each of the MetS components.
Results
The MetS prevalence was 60%. We found a statistically significant association between rs9939609-FTO and hyperglycemia in the dominant model (OR 2.6; 95% CI 1.3–5.3; p = 0.007).
Conclusions
Women from Mayan communities of Chiapas presented a high prevalence of MetS and a relevant association of the FTO variant with hyperglycemia. This is the first study carried out in these Mayan indigenous communities from Chiapas.
Funder
Consejo Nacional de Ciencia y Tecnología
Publisher
Springer Science and Business Media LLC
Subject
Physiology (medical),Public Health, Environmental and Occupational Health,Anthropology,Orthopedics and Sports Medicine,Physiology,Human Factors and Ergonomics
Cited by
2 articles.
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