Author:
Hajipour Azadeh,Ardekanizadeh Naeemeh Hassanpour,Roumi Zahra,Shekari Soheila,Aminnezhad Kavkani Bahareh,Shalmani Seyedeh Hayedeh Mousavi,Bahar Bojlul,Tajadod Shirin,Ajami Marjan,Tabesh Ghasem Azizi,Gholamalizadeh Maryam,Doaei Saeid
Abstract
Abstract
Background
Colorectal cancer (CRC) is one of the most common cancers in the world. Some dietary factors such as fat intake have been identified as the risk factors for CRC. This study aimed to investigate the effect of fat mass and obesity-associated (FTO) gene rs9939609 polymorphism on the association between CRC and different types of dietary fats.
Methods
This case-control study was performed on 135 CRC cases and 294 healthy controls in Tehran, Iran. Data on demographic factors, anthropometric measurements, physical activity, the intake of different types of dietary fats, and FTO gene rs9939609 polymorphism was collected from all participants. The association between cancer and dietary fat intake in individuals with different FTO genotypes was assessed using different models of logistic regression.
Results
Oleic acid intake was higher in the case group compared to the control group in both people with TT (7.2±3.46 vs. 5.83±3.06 g/d, P=0.02) and AA/AT genotypes (8.7±6.23 vs. 5.57 ±3.2 g/d, P<0.001). Among carriers of AA/AT genotypes of FTO rs9939609 polymorphism, a positive association was found between CRC and higher intakes of oleic acid (OR=1.12, CI95% 1.03–1.21, P=0.01) and cholesterol (OR=1.01, CI95% 1.00–1.02; P=0.01) after adjusting for age, sex, physical activity, alcohol use, smoking, calorie intake, and body mass index.
Conclusion
Higher intakes of cholesterol and oleic acid were associated with a higher risk of CRC in FTO-risk allele carriers. The association of CRC and dietary fat may be influenced by the FTO genotype. Further longitudinal studies are warranted to confirm these findings.
Publisher
Springer Science and Business Media LLC
Subject
Physiology (medical),Public Health, Environmental and Occupational Health,Anthropology,Orthopedics and Sports Medicine,Physiology,Human Factors and Ergonomics