How to design a dose-finding study using the continual reassessment method

Author:

Wheeler Graham M.ORCID,Mander Adrian P.,Bedding Alun,Brock Kristian,Cornelius Victoria,Grieve Andrew P.,Jaki Thomas,Love Sharon B.,Odondi Lang’o,Weir Christopher J.,Yap Christina,Bond Simon J.

Funder

MRC Network of Hubs for Trials Methodology Research

Medical Research Council

National Institute for Health Research

Cancer Research UK

Publisher

Springer Science and Business Media LLC

Subject

Health Informatics,Epidemiology

Reference97 articles.

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2. Carter SK. Study design principles for the clinical evaluation of new drugs as developed by the chemotherapy programme of the National Cancer Institute. In: Staquet MJ, editor. The Design of Clinical Trials in Cancer Therapy. Editions Scientifique Europe; 1973. p. 242–89.

3. Le Tourneau C, Lee JJ, Siu LL. Dose escalation methods in phase I cancer clinical trials. J Natl Cancer Inst. 2009;101:708–20.

4. Rogatko A, Schoeneck D, Jonas W, Tighiouart M, Khuri FR, Porter A. Translation of innovative designs into phase I trials. J Clin Oncol. 2007;25:4982–6.

5. Chiuzan C, Shtaynberger J, Manji GA, Duong JK, Schwartz GK, Ivanova A, et al. Dose-finding designs for trials of molecularly targeted agents and immunotherapies. J Biopharm Stat. 2017;27:477–94.

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