Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer’s APP/PSEN1 mice by gene targeting of diabetes/Alzheimer’s-related Sorcs1-Reference-Cited by-同舟云学术

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Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer’s APP/PSEN1 mice by gene targeting of diabetes/Alzheimer’s-related Sorcs1

Published:2016-02-25 Issue:1 Volume:4 Page:
ISSN:2051-5960
Container-title:Acta Neuropathologica Communications
language:en
Short-container-title:acta neuropathol commun

Author:

Knight Elysse M.,Ruiz Henry H.,Kim Soong Ho,Harte Jessica C.,Hsieh Wilson,Glabe Charles,Klein William L.,Attie Alan D.,Buettner Christoph,Ehrlich Michelle E.,Gandy Sam

Funder

National Institutes of Health

American Diabetes Association

Rehabilitation Research and Development Service

Biomedical Laboratory Research and Development, VA Office of Research and Development

National Institute on Drug Abuse

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Neurology (clinical),Pathology and Forensic Medicine

Link

http://link.springer.com/content/pdf/10.1186/s40478-016-0282-y.pdf

Reference70 articles.

1. Ahtiluoto S, Polvikoski T, Peltonen M, Solomon A, Tuomilehto J, Winblad B, et al. Diabetes, Alzheimer disease, and vascular dementia: a population-based neuropathologic study. Neurology. 2010;75:1195–202. doi: 10.1212/WNL.0b013e3181f4d7f8 .

2. Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, et al. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci U S A. 2005;102:13461–6. doi: 10.1073/pnas.0503689102 .

3. Arvanitakis Z, Schneider JA, Wilson RS, Li Y, Arnold SE, Wang Z, et al. Diabetes is related to cerebral infarction but not to AD pathology in older persons. Neurology. 2006;67:1960–5. doi: 10.1212/01.wnl.0000247053.45483.4e .

4. Baker LD, Cross DJ, Minoshima S, Belongia D, Watson GS, Craft S. Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes. Arch Neurol. 2011;68:51–7. doi: 10.1001/archneurol.2010.225 .

5. Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer’s disease prevalence. Lancet Neurol. 2011;10:819–28. doi: 10.1016/S1474-4422(11)70072-2 .

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