Immunological analysis of phase II glioblastoma dendritic cell vaccine (Audencel) trial: immune system characteristics influence outcome and Audencel up-regulates Th1-related immunovariables

Author:

Erhart FriedrichORCID,Buchroithner Johanna,Reitermaier René,Fischhuber Katrin,Klingenbrunner Simone,Sloma Ido,Hibsh Dror,Kozol Renana,Efroni Sol,Ricken Gerda,Wöhrer Adelheid,Haberler Christine,Hainfellner Johannes,Krumpl Günther,Felzmann Thomas,Dohnal Alexander M.,Marosi Christine,Visus Carmen

Funder

Austrian Research Promotion Agency

European Program IAPP-24

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Neurology (clinical),Pathology and Forensic Medicine

Reference38 articles.

1. Berghoff AS, Kiesel B, Widhalm G, Rajky O, Ricken G, Wöhrer A et al (2014 [cited 2015 Jan 5]) Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma. Neuro Oncol. 2015;17(8):1064–75. https://doi.org/10.1093/neuonc/nou307 . Epub 2014 Oct 29.

2. Buchroithner J, Erhart F, Pichler J, Widhalm G, Preusser M, Stockhammer G et al (2018) Audencel Immunotherapy Based on Dendritic Cells Has No Effect on Overall and Progression-Free Survival in Newly Diagnosed Glioblastoma: A Phase II Randomized Trial. Cancers 10:372 Multidisciplinary Digital Publishing Institute; 2018 [cited 2018 Oct 8];10:372. Available from: https://www.mdpi.com/2072-6694/10/10/372

3. Chen W, Huang N-T, Li X, Yu ZTF, Kurabayashi K, Fu J (2013) Emerging microfluidic tools for functional cellular immunophenotyping: a new potential paradigm for immune status characterization. Front Oncol 3:98 Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3631762&tool=pmcentrez&rendertype=abstract

4. Czerkinsky CC, Nilsson LA, Nygren H, Ouchterlony O, Tarkowski A. A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells. J Immunol Methods. 1983 [cited 2017 Jul 4];65:109–121. Available from: http://www.ncbi.nlm.nih.gov/pubmed/6361139

5. Everson RG, Jin RM, Wang X, Safaee M, Scharnweber R, Lisiero DN, et al. Cytokine responsiveness of CD8(+) T cells is a reproducible biomarker for the clinical efficacy of dendritic cell vaccination in glioblastoma patients. J Immunother cancer. 2014 [cited 2018 Aug 20];2:10. Available from: http://jitc.biomedcentral.com/articles/10.1186/2051-1426-2-10

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