Evaluation of a novel antibody to define histone 3.3 G34R mutant brain tumours

Author:

Haque Farhana,Varlet Pascale,Puntonet Julien,Storer Lisa,Bountali Aikaterini,Rahman Ruman,Grill Jacques,Carcaboso Angel M,Jones Chris,Layfield Robert,Grundy Richard G

Funder

Billie Butterfly Fund, Brain tumour Charity

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Neurology (clinical),Pathology and Forensic Medicine

Reference15 articles.

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2. Bechet D, Gielen GGH, Korshunov A, Pfister SM, Rousso C, Faury D, Fiset P-O, Benlimane N, Lewis PW, Lu C, David Allis C, Kieran MW, Ligon KL, Pietsch T, Ellezam B, Albrecht S, Jabado N (2014) Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas. Acta Neuropathol 128:733–741. doi: 10.1007/s00401-014-1337-4

3. Bender S, Tang Y, Lindroth AM, Hovestadt V, Jones DTW, Kool M, Zapatka M, Northcott PA, Sturm D, Wang W, Radlwimmer B, Højfeldt JW, Truffaux N, Castel D, Schubert S, Ryzhova M, Seker-Cin H, Gronych J, Johann PD, Stark S, Meyer J, Milde T, Schuhmann M, Ebinger M, Monoranu C-M, Ponnuswami A, Chen S, Jones C, Witt O, Collins VP, von Deimling A, Jabado N, Puget S, Grill J, Helin K, Korshunov A, Lichter P, Monje M, Plass C, Cho Y-J, Pfister SM (2013) Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell 24:660–672. doi: 10.1016/j.ccr.2013.10.006

4. Bjerke L, Mackay A, Nandhabalan M, Burford A, Jury A, Popov S, Bax DA, Carvalho D, Taylor KR, Vinci M, Bajrami I, IM MG, Lord CJ, Reis RM, Hargrave D, Ashworth A, Workman P, Jones C (2013) Histone H3.3 mutations drive pediatric Glioblastoma through Upregulation of MYCN. Cancer Discov 3:512–519. doi: 10.1158/2159-8290.CD-12-0426

5. Chan K-M, Fang D, Gan H, Hashizume R, Yu C, Schroeder M, Gupta N, Mueller S, James CD, Jenkins R, Sarkaria J, Zhang Z (2013) The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes dev 27:985–990. doi: 10.1101/gad.217778.113

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