Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription
Author:
Funder
Bristol-Myers Squibb
National Institute on Aging
Rainwater Charitable Foundation
Harrison Gardner, Jr. Innovation Award
Publisher
Springer Science and Business Media LLC
Link
https://link.springer.com/content/pdf/10.1186/s40478-024-01844-6.pdf
Reference29 articles.
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2. Bowles KR, Pugh DA, Oja L-M, Jadow BM, Farrell K, Whitney K, Sharma A, Cherry JD, Raj T, Pereira AC, Crary JF, Goate AM (2022) Dysregulated coordination of MAPT exon 2 and exon 10 splicing underlies different tau pathologies in PSP and AD. Acta Neuropathol 143:225–243. https://doi.org/10.1007/s00401-021-02392-2
3. Ciryam P, Kundra R, Freer R, Morimoto RI, Dobson CM, Vendruscolo M (2016) A transcriptional signature of Alzheimer’s disease is associated with a metastable subproteome at risk for aggregation. Proc Natl Acad Sci U S A 113:4753–4758. https://doi.org/10.1073/pnas.1516604113
4. Conrad C, Andreadis A, Trojanowski JQ, Dickson DW, Kang D, Chen X, Wiederholt W, Hansen L, Masliah E, Thal LJ, Katzman R, Xia Y, Saitoh T (1997) Genetic evidence for the involvement of tau in progressive supranuclear palsy. Ann Neurol 41:277–281. https://doi.org/10.1002/ana.410410222
5. Ezerskiy LA, Schoch KM, Sato C, Beltcheva M, Horie K, Rigo F, Martynowicz R, Karch CM, Bateman RJ, Miller TM (2022) Astrocytic 4R tau expression drives astrocyte reactivity and dysfunction. JCI Insight 7:e152012. https://doi.org/10.1172/jci.insight.152012
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